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Hormone replacement therapy linked to more frequent, longer migraines. A new meta-analysis finds that postmenopausal women on HRT experience more frequent and longer-lasting migraines — though not more severe ones. Researchers say individualized treatment decisions and more clinical trials are still needed before drawing firm conclusions.
Hormone replacement therapy linked to more frequent, longer migraines
A systematic review and meta-analysis presented at The Menopause Society's annual meeting suggests that hormone replacement therapy (HRT) may increase migraine burden in postmenopausal women — specifically making migraines more frequent and longer in duration, though not more severe. The analysis, led by Dr. Flavia Fairbanks Ruano of the University of Miami, pooled data from five studies involving 23,702 women.
Experts caution that the findings don't tell the whole story. Women with migraines may be more likely to seek HRT for vasomotor symptoms in the first place, meaning the results could reflect pre-existing differences between groups rather than a direct causal effect. HRT still remains the most effective treatment for bothersome menopause symptoms and can be used safely in many women with migraines.
By the Numbers
Why it matters: For the millions of women navigating both menopause and migraines, this research highlights the need for personalized care — ideally with neurologists and menopause specialists working together to fine-tune treatment throughout the transition.
