Leave a little sharper than you arrived.

News, calculators, learning and daily puzzles — pick any one and leave a little further along.

Today’s puzzle

FDA approves first immunotherapy for locally advanced rectal cancer, potentially sparing patients from surgery and chemo

The FDA has granted accelerated approval to dostarlimab (Jemperli) as the first immunotherapy for adults with stage II/III MSI-H/dMMR locally advanced rectal cancer. Backed by the phase 2 AZUR-1 trial, nearly 3 in 4 patients avoided surgery, radiation, and chemotherapy after more than 2 years of follow-up. This marks a major shift away from treatments that often cause lasting bowel, bladder, sexual, and fertility complications.

Healio · 2 min

FDA greenlights Zilbrysq autoinjector for myasthenia gravis patients

Healio · 2 min

FDA approves first antisense therapy for chronic hepatitis B — and it can actually cure it

OncLive · 2 min

FDA upgrades pembrolizumab approval for TMB-H solid tumors — with a higher mutation threshold

Everything on Curie.MD

NeurologyPlay & LearnLearn what’s new in your field, a few minutes at a time.Start learning CardiologyCalculatorsEnter the case once. See every relevant score, side by side.Open a calculator All fieldsDaily GamesThree new clinical puzzles every morning.Play today

Get Curie’s Weekly Dose

What changed in clinical practice, policy, and coverage, and what it means for your patients.

Subscribe free Free. Weekly. Unsubscribe anytime.