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News
Contact lens wearers, take note. A new phase 4 trial found that using Miebo (perfluorohexyloctane) eye drops while wearing contacts significantly reduced end-of-day dryness and discomfort — and even extended how long patients could comfortably wear their lenses. The findings challenge the current label recommendation to wait 30 minutes after instilling the drop before putting in contacts.
Contact lens wearers struggling with end-of-day dryness may have a new ally. A phase 4 multicenter prospective trial presented at Academy 2026 found that using Miebo (perfluorohexyloctane ophthalmic solution, Bausch + Lomb) directly during contact lens wear — not just before or after — significantly reduced dryness, discomfort, and lens-related symptoms over 30 days.
The study enrolled 104 habitual contact lens wearers who instilled Miebo four times daily: once before putting in their lenses and three times while wearing them. Researchers found no serious safety signals, with only mild-to-moderate adverse events in 4.8% of eyes and just one patient discontinuing the study.
By the Numbers:
Why it matters: Contact lens dropout is a real problem, with end-of-day discomfort being one of the top reasons patients quit wearing lenses. These findings suggest Miebo's monolayer mechanism works over contact lenses just as it does over the natural tear film — potentially giving eye care providers a practical tool to keep patients in their lenses longer.
