GLP-1 medications are powerful — but they're not a stand-alone solution. At the Association of Diabetes Care & Education Specialists (ADCES26) annual meeting, registered dietitians Kathleen Fincher and Casey Fiocchi made the case that long-term success with GLP-1s hinges on comprehensive lifestyle support, not just the prescription itself.

The duo outlined how GLP-1s work — slowing gastric emptying, reducing hunger signals in the brain, and improving glucose regulation — while also flagging real risks that can emerge without proper monitoring. Between 15% and 45% of patients experience nausea or vomiting, and longer-term concerns include nutrient deficiencies, loss of lean muscle mass, and even kidney injury or pancreatitis.

To get the most out of GLP-1 therapy, Fiocchi recommended a thorough patient assessment before prescribing, personalized meal planning with a registered dietitian, and both aerobic and resistance exercise to preserve muscle. Fincher emphasized using shared decision-making and SMART goals to build lasting habits.

Key Takeaways:

• Protein intake of 1.2–1.6 g per kg of healthy body weight is recommended to preserve lean muscle mass
• Clinicians should set per-meal protein goals rather than daily totals to make targets more achievable
• Resistance and aerobic exercise can help maintain muscle, mood, and glucose control
• Patient handouts and dietitian partnerships can reinforce education between visits

Why it matters: As GLP-1 prescriptions surge, clinicians face growing pressure to support patients beyond the prescription pad. Without structured nutrition and lifestyle guidance, patients may see short-term results but struggle to maintain them — or face preventable complications.