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Getting the latest healthcare news for you
Getting the latest healthcare news for you
A phase 3 trial found that a once-nightly 0.75% phentolamine ophthalmic solution significantly improved dim-light vision and reduced glare, halos, and starbursts in patients with night vision difficulties. Over 20% of treated patients gained three or more lines on an eye chart by day 15, compared to just 3% on placebo. Side effects were mild and temporary.
Struggling to see at night? A new eye drop may help.
A phase 3 clinical trial published in the American Journal of Ophthalmology found that a once-nightly eye drop — 0.75% phentolamine ophthalmic solution — meaningfully improved dim-light vision and reduced bothersome symptoms like glare, halos, and starbursts. The multicenter, placebo-controlled study enrolled 145 adults with self-reported night vision problems, dilated pupils of at least 5 mm in low light, and reduced visual acuity under dim conditions.
The drop works by modestly constricting the pupil — without engaging the ciliary muscle — which helps sharpen vision in low-light settings. Side effects were generally mild, including eye discomfort, a metallic taste, and mild redness.
By the Numbers:
Why it matters: Night vision impairment affects millions — especially those with a history of refractive surgery or corneal conditions. A well-tolerated, once-nightly drop could offer a practical, non-surgical option to improve quality of life and safety, particularly for nighttime driving.
